Research
Division faculty have substantive interests in the areas of osteoporosis, osteoarthritis, diabetes, women’s health and other areas. Some of the larger projects that are currently being overseen by Division faculty include the following:
Osteoarthritis Initiative (OAI) is a longitudinal observational study of imaging, biochemical and genetic biomarkers of knee osteoarthritis incidence and progression that is jointly funded by NIH and several pharmaceutical companies.
HORIZON Pivotal Fracture Trial is testing once-yearly infusions of Zoledronic acid vs. placebo for fracture reduction and is funded by Novartis. The trial is being conducted in over 7700 participants in 230 international clinical centers and will be completed in 2006.
Study of Osteoporotic Fractures (SOF) is an observational study of 9704 women begun in 1986 with a goal of identifying risk factors for fractures. The study has published over 250 papers in osteoporosis and other areas of women’s health.
ACCORD BONE: The NIH-funded ACCORD BONE trial is adding measures of fractures, falls and bone mineral density to the clinical trial Action to Control Cardiovascular Risk in Diabetes (ACCORD) to determine if intensive glycemic control improves these outcomes in older adults with type 2 diabetes.
San Francisco Coordinating Center
The large studies are run through the San Francisco Coordinating Center which is a collaborative endeavor of Division faculty and faculty at the California Pacific Medical Center (CPMC) Research Institute. The SFCC includes approximately 12 primary faculty and about 80 staff in areas ranging from project management, data management, data analysis, research support.
A more complete list of SF Coordinating Center projects can be obtained at the SFCC website.